The Changing Role of University Computing Centers: Toward Variety of Networking, Computing and Educational Services

What are the roles of computing centers within academic and research community today, has their time passed away and they are just dinosaurs belonging to history or their time is just coming again with new tasks, challenges and high expectations? In this article we analyzed the needs of academic and research community in the field of information and communication technology and came to the conclusion that in the next period we should expect only further significant growth (in terms of quantity as well as variety) of those needs. Considering that fact, we foresee and discuss the range of potential roles of computing centers in an academic and research community in the near future. Our arguments are verified through the case of University Computing Centre (SRCE) University of Zagreb, which is celebrating thirty years of successful leading in implementation of latest information and communication technologies and serving the needs of academic and research community in Croatia

Editorial

Welcome to our regular edition of CIT devoted to the 2011 ITI (Information Technology Interfaces) Conference. The following 10 papers (out of 100) were selected from those originally published in the ITI 2011 Conference Proceedings (IEEE Catalog Number CFP11498-PRT). As in previous years, papers were selected after having received high ratings from both of their respective international reviewers and as being representative of the broad scope character of the ITI Conference in terms of the topics solicited over these last 33 years. Out of 11 conference topics, eight are represented by at least one paper

Editorial

Welcome to our regular edition of CIT devoted to the 2008 ITI (Information Technology Interfaces) Conference. The following 15 papers (out of 148) were selected from those originally published in the ITI 2008 Conference Proceedings (IEEE Catalog Number CFP08498-PRT). As in previous years, papers were selected after having received high ratings from both of their respective international reviewers and as being representative of the broad scope character of the ITI Conference in terms of topics solicited over these last 30 years

Editorial

Welcome to our regular edition of CIT devoted to the 2008 ITI (Information Technology Interfaces) Conference. The following 15 papers (out of 148) were selected from those originally published in the ITI 2008 Conference Proceedings (IEEE Catalog Number CFP08498-PRT). As in previous years, papers were selected after having received high ratings from both of their respective international reviewers and as being representative of the broad scope character of the ITI Conference in terms of topics solicited over these last 30 years

Plasma-Activated Medium Potentiates the Immunogenicity of Tumor Cell Lysates for Dendritic Cell-Based Cancer Vaccines

Autologous dendritic cells (DCs)-based vaccines are considered quite promising for cancer immunotherapy due to their exquisite potential to induce tumor antigen-specific cytotoxic T cells. However, a lack of efficient protocols for inducing immunogenic tumor antigens limits the efficacy of DC-based cancer vaccines. Here, we found that a plasma-activated medium (PAM) induces immunogenic cell death (ICD) in tumor cells but not in an immortalized L929 cell line or human peripheral blood mononuclear cells. PAM induced an accumulation of reactive oxygen species (ROS), autophagy, apoptosis, and necrosis in a concentration-dependent manner. The tumor lysates prepared after PAM treatment displayed increased immunogenicity in a model of human monocyte-derived DCs, compared to the lysates prepared by a standard freezing/thawing method. Mature DCs loaded with PAM lysates showed an increased maturation potential, as estimated by their increased expression of CD83, CD86, CD40, IL-12/IL-10 production, and attenuated PDL1 and ILT-4 expression, compared to the DCs treated with control tumor lysates. Moreover, in co-culture with allogeneic T cells, DCs loaded with PAM-lysates increased the proportion of cytotoxic IFN-γ+ granzyme A+ CD8+ T cells and IL-17A-producing T cells and preserved the Th1 response. In contrast, control tumor lysates-treated DCs increased the frequency of Th2 (CD4+IL-4+), CD4, and CD8 regulatory T cell subtypes, none of which was observed with DCs loaded with PAM-lysates. Cumulatively, these results suggest that the novel method for preparing immunogenic tumor lysates with PAM could be suitable for improved DC-based immunotherapy of cancer patients

DABAR - the national infrastructure for digital repositories

Having recognized the need for a national digital asset management infrastructure, SRCE – University of Zagreb University Computing Centre in association with a number of research and higher education institutions in Croatia built a national repository system called DABAR – Digital academic archives and repositories. DABAR provides research and higher education institutions with the common infrastructure necessary to establish a secure, reliable and interoperable institutional repositories in a simple way. Dabar allows institutions to manage their digital assets without the need to deal with technical issues related to the implementation and maintenance of digital repositories. Until the middle of March 2017, DABAR was used to build two national repositories and 109 repositories of Croatian research and higher education institutions. Currently, it supports curation of electronic theses and dissertations, and papers published in electronic journals. The support for conference papers, book chapters, artistic works (photographs and other audio - visual objects) is being actively developed and a plan to build a support for managing research data sets and educational resources is in place. The DABAR platform and the community gathered around it are actively promoting Open Access to the results of research and to educational modules and resources

Croatian Plan for Open Science

A presentation of the draft for the Croatian Plan for Open Science. At the presentation, the focus was also on the vision and primary objectives of open science in general

Srce : Sveučilišni računski centar Sveučilišta u Zagrebu : središte hrvatske nacionalne akademske i istraživačke e-infrastrukture

Prezentacija o djelatnosti Sveučilišnog računskog centra (Srce) Sveučilišta u Zagrebu